{"id":22816,"date":"2026-09-07T06:24:12","date_gmt":"2026-09-07T06:24:12","guid":{"rendered":"https:\/\/mdforlives.com\/insights\/?p=22816"},"modified":"2026-10-01T18:42:37","modified_gmt":"2026-10-01T18:42:37","slug":"overall-survival-in-oncology-when-should-surrogate-endpoints-count","status":"publish","type":"post","link":"https:\/\/mdforlives.com\/insights\/doctors-and-other-healthcare-professionals\/oncology-and-hematology\/overall-survival-in-oncology-when-should-surrogate-endpoints-count\/","title":{"rendered":"Overall Survival in Oncology:\u00a0When Should Surrogate Endpoints Count?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"22816\" class=\"elementor elementor-22816\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6289e5d e-flex e-con-boxed e-con e-parent\" data-id=\"6289e5d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fe4609a e-con e-atomic-element e-flexbox-base e-default-div e-bad22e0 \" data-id=\"fe4609a\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"fe4609a\" data-e-type=\"e-flexbox\" data-id=\"fe4609a\">\n    <div class=\"elementor-element elementor-element-fe591e0 e-con e-atomic-element e-flexbox-base e-default-div e-ae3d676 \" data-id=\"fe591e0\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"fe591e0\" data-e-type=\"e-flexbox\" data-id=\"fe591e0\">\n    \t\t<div class=\"elementor-element elementor-element-d9e5d59 elementor-widget elementor-widget-shortcode\" data-id=\"d9e5d59\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><nav class=\"custom-breadcrumb\"><a href=\"https:\/\/mdforlives.com\/\">Home<\/a><span>\/<\/span><a href=\"https:\/\/mdforlives.com\/insights\/\">Trends<\/a><span>\/<\/span><a href=\"https:\/\/mdforlives.com\/insights\/category\/doctors-and-other-healthcare-professionals\/oncology-and-hematology\/\">Oncology &amp; Hematology<\/a><span>\/<\/span><span class=\"current\">Overall Survival in Oncology:\u00a0When Should Surrogate Endpoints Count?<\/span><\/nav><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5847a5d elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"5847a5d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"hero-badge\">Oncology &amp; Hematology Insight Report<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b74071 elementor-widget elementor-widget-heading\" data-id=\"2b74071\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Overall Survival in Oncology: <span class=\"Green\">When Should Surrogate Endpoints Count?<\/span><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c091626 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"c091626\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"hero-sub\">A peer-level look at how oncology and hematology clinicians weigh overall survival against PFS\/EFS, MRD and ctDNA, quality of life, toxicity, reimbursement, and the evidence needed to trust accelerated approvals.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ef7a989 e-con-full e-flex e-con e-parent\" data-id=\"ef7a989\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ab44051 elementor-widget elementor-widget-text-editor\" data-id=\"ab44051\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Audience: <strong>Oncology &amp; Hematology Clinicians<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-593a903 elementor-widget elementor-widget-text-editor\" data-id=\"593a903\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Countries: <strong>6<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d532a9 elementor-widget elementor-widget-text-editor\" data-id=\"0d532a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Completion Rate: <strong>70.8%<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2d3535 elementor-widget elementor-widget-text-editor\" data-id=\"d2d3535\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>SGID: <strong>8945208<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8438619 e-con-full e-flex e-con e-child\" data-id=\"8438619\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9f81ae0 elementor-align-center elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"9f81ae0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/09\/Final-Insight-Report_Overall-Survival-in-Oncology_-When-Should-Surrogate-Endpoints-Count.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Download Full Report<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5247bde elementor-align-left elementor-widget__width-initial elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"5247bde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/mdforlives.com\/us\/signup\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Join the Panel<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n<div class=\"elementor-element elementor-element-9fdbd5d e-con e-atomic-element e-flexbox-base e-default-div e-a138f19 \" data-id=\"9fdbd5d\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"9fdbd5d\" data-e-type=\"e-flexbox\" data-id=\"9fdbd5d\">\n    <div class=\"elementor-element elementor-element-d4f6ce8 e-flex e-con-boxed e-con e-parent\" data-id=\"d4f6ce8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c4ad025 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"c4ad025\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>-Hero findings<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10725b1 elementor-widget elementor-widget-counter\" data-id=\"10725b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"55.8\" data-from-value=\"0\" data-delimiter=\",\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\">%<\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3be869 elementor-widget elementor-widget-text-editor\" data-id=\"b3be869\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"stat-hero-label\"><div class=\"stat-hero-label\"><div class=\"stat-hero-label\"><div class=\"stat-hero-label\"><div class=\"stat-hero-label\"><div class=\"stat-hero-label\"><div class=\"stat-hero-label\"><div class=\"stat-hero-label\"><div class=\"stat-hero-label\"><div class=\"stat-hero-label\"><article class=\"hero-main\"><div class=\"metric-note\">view a regulator-approved drug with a robust PFS\/EFS gain but no OS benefit as moderately acceptable, prescribing it while explaining that longer total lifespan has not been confirmed.<\/div><\/article><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9eb16ba e-grid e-con-full e-con e-child\" data-id=\"9eb16ba\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1a5882f elementor-widget elementor-widget-counter\" data-id=\"1a5882f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t<div class=\"elementor-counter-title\">say OS is necessary in late-stage or relapsed disease, while surrogate endpoints should replace it in selected early, adjuvant, or certain settings.<\/div>\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"40.4\" data-from-value=\"0\" data-delimiter=\",\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\">%<\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-104253e elementor-widget elementor-widget-counter\" data-id=\"104253e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t<div class=\"elementor-counter-title\">identify hematologic malignancies as the setting most ready for negative MRD\/ctDNA to serve as a standalone approval endpoint.<\/div>\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"46.2\" data-from-value=\"0\" data-delimiter=\",\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\">%<\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f3054dc elementor-widget elementor-widget-counter\" data-id=\"f3054dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t<div class=\"elementor-counter-title\">say symptom palliation, preserved function, and daily quality of life most often drive the final late-line shared decision.<\/div>\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"40.4\" data-from-value=\"0\" data-delimiter=\",\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\">%<\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb21654 elementor-widget elementor-widget-counter\" data-id=\"eb21654\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t<div class=\"elementor-counter-title\">say mandatory real-world evidence tracking alongside confirmatory trials would most improve confidence in accelerated approvals.<\/div>\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"43.1\" data-from-value=\"0\" data-delimiter=\",\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\">%<\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n\n<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-34c1647 e-con e-atomic-element e-flexbox-base e-default-div e-34c1647-99a6822 \" data-id=\"34c1647\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"34c1647\" data-e-type=\"e-flexbox\" data-id=\"34c1647\">\n    <div class=\"elementor-element elementor-element-7349f85 e-flex e-con-boxed e-con e-parent\" data-id=\"7349f85\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d4d6e7 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"6d4d6e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #004c97;\">&#8211; Quick Read \u2014 Key Findings<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-205f104 elementor-pagination-type-bullets elementor-pagination-position-outside elementor-widget elementor-widget-n-carousel\" data-id=\"205f104\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;carousel_items&quot;:[{&quot;slide_title&quot;:&quot;Slide #1&quot;,&quot;_id&quot;:&quot;aea3862&quot;},{&quot;slide_title&quot;:&quot;Slide #2&quot;,&quot;_id&quot;:&quot;ee71ba3&quot;},{&quot;slide_title&quot;:&quot;Slide #3&quot;,&quot;_id&quot;:&quot;755a9c0&quot;},{&quot;slide_title&quot;:&quot;Slide #4&quot;,&quot;_id&quot;:&quot;e801683&quot;},{&quot;slide_title&quot;:&quot;Slide #5&quot;,&quot;_id&quot;:&quot;a99beb4&quot;},{&quot;slide_title&quot;:&quot;Slide #6&quot;,&quot;_id&quot;:&quot;a1ee942&quot;}],&quot;slides_to_show&quot;:&quot;2&quot;,&quot;slides_to_show_tablet&quot;:&quot;2&quot;,&quot;slides_to_show_mobile&quot;:&quot;1&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500,&quot;offset_sides&quot;:&quot;none&quot;,&quot;pagination&quot;:&quot;bullets&quot;,&quot;image_spacing_custom&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;image_spacing_custom_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;image_spacing_custom_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-carousel.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-carousel swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Carousel\" dir=\"ltr\">\n\t\t\t<div class=\"swiper-wrapper\" aria-live=\"off\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" data-slide=\"1\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"1 of 6\">\n\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1a0273a e-flex e-con-boxed e-con e-child\" data-id=\"1a0273a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bc77768 elementor-widget elementor-widget-text-editor\" data-id=\"bc77768\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"quick-no\">01 \/\/ OS benchmark<\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c964f14 elementor-widget elementor-widget-heading\" data-id=\"c964f14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">40.4%\n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f10c57b elementor-widget elementor-widget-text-editor\" data-id=\"f10c57b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><p>Make OS setting-specific<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01bfa08 elementor-widget elementor-widget-text-editor\" data-id=\"01bfa08\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"quick-card\"><p>The largest group keeps OS central in late-stage or relapsed disease but supports earlier surrogate endpoints in selected settings.<\/p><\/article><article class=\"quick-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" data-slide=\"2\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"2 of 6\">\n\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ca74090 e-flex e-con-boxed e-con e-child\" data-id=\"ca74090\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b7ae459 elementor-widget elementor-widget-text-editor\" data-id=\"b7ae459\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"quick-no\">02 \/\/ Benefit-risk<\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a15e804 elementor-widget elementor-widget-heading\" data-id=\"a15e804\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">59.6%\n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0da0fdd elementor-widget elementor-widget-text-editor\" data-id=\"0da0fdd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><p>Modest OS gains trigger patient selection<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5086dd0 elementor-widget elementor-widget-text-editor\" data-id=\"5086dd0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><div class=\"card-label\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"quick-card\"><article class=\"quick-card\"><p>Most would offer a higher-toxicity regimen primarily to younger, fit patients who prioritize maximum survival.<\/p><\/article><article class=\"quick-card\"><\/article><\/article><article class=\"quick-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" data-slide=\"3\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"3 of 6\">\n\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-64f8987 e-flex e-con-boxed e-con e-child\" data-id=\"64f8987\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6b3d405 elementor-widget elementor-widget-text-editor\" data-id=\"6b3d405\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"quick-no\">03 \/\/ MRD\/ctDNA<\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-18978ee elementor-widget elementor-widget-heading\" data-id=\"18978ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">46.2%\n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b50726c elementor-widget elementor-widget-text-editor\" data-id=\"b50726c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><p>Hematologic malignancies look most ready<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-128bf0f elementor-widget elementor-widget-text-editor\" data-id=\"128bf0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"quick-card\"><p>Clinicians place the strongest standalone-endpoint confidence in diseases such as myeloma, leukemia, and lymphoma.<\/p><\/article><article class=\"quick-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" data-slide=\"4\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"4 of 6\">\n\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3f0d302 e-flex e-con-boxed e-con e-child\" data-id=\"3f0d302\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7cce74c elementor-widget elementor-widget-text-editor\" data-id=\"7cce74c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"quick-no\">04 \/\/ De-escalation<\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1456fec elementor-widget elementor-widget-heading\" data-id=\"1456fec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">46.2%\n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-358aad8 elementor-widget elementor-widget-text-editor\" data-id=\"358aad8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><p>MRD changes intensity before it stops therapy<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-834f9d1 elementor-widget elementor-widget-text-editor\" data-id=\"834f9d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"quick-card\"><p>The most common response to persistent MRD negativity is dose or frequency reduction, not complete cessation.<\/p><\/article><article class=\"quick-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" data-slide=\"5\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"5 of 6\">\n\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a2cca76 e-flex e-con-boxed e-con e-child\" data-id=\"a2cca76\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-06bb76e elementor-widget elementor-widget-text-editor\" data-id=\"06bb76e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"quick-no\">05 \/\/ Late-line decisions<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-611a867 elementor-widget elementor-widget-heading\" data-id=\"611a867\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">40.4%\n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70ee9ed elementor-widget elementor-widget-text-editor\" data-id=\"70ee9ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><p>Function and symptom control can lead<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-588fe28 elementor-widget elementor-widget-text-editor\" data-id=\"588fe28\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"quick-card\"><p>In advanced disease discussions, palliation, performance status, and daily QoL outrank OS as the single largest decision driver.<\/p><\/article><article class=\"quick-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" data-slide=\"6\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"6 of 6\">\n\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-022b3b4 e-flex e-con-boxed e-con e-child\" data-id=\"022b3b4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a84ba8d elementor-widget elementor-widget-text-editor\" data-id=\"a84ba8d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"card-index\"><div class=\"quick-no\">06 \/\/ Accelerated approval<\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bef5d82 elementor-widget elementor-widget-heading\" data-id=\"bef5d82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">43.1%\n<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0172f5 elementor-widget elementor-widget-text-editor\" data-id=\"d0172f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><div class=\"card-label\"><p>RWE is the preferred confidence-builder<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-208dcf9 elementor-widget elementor-widget-text-editor\" data-id=\"208dcf9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"card-label\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><article class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-outer\"><div id=\"qrTrack\" class=\"carousel-track\"><article class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-outer\"><div id=\"qrTrack\" class=\"carousel-track\"><article class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-outer\"><div id=\"qrTrack\" class=\"carousel-track\"><article class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-outer\"><div id=\"qrTrack\" class=\"carousel-track\"><article class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-outer\"><div id=\"qrTrack\" class=\"carousel-track\"><article class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-outer\"><div id=\"qrTrack\" class=\"carousel-track\"><article class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-outer\"><div id=\"qrTrack\" class=\"carousel-track\"><article class=\"carousel-card\"><div class=\"card-desc\"><div class=\"carousel-outer\"><div id=\"qrTrack\" class=\"carousel-track\"><article class=\"carousel-card\"><div class=\"card-desc\"><section class=\"quick-section\"><div class=\"container\"><div class=\"quick-track\" aria-label=\"Quick read findings\"><article class=\"quick-card\"><p>Mandatory real-world evidence tracking alongside confirmatory trials leads the policy changes clinicians want most.<\/p><\/article><\/div><\/div><\/section><\/div><\/article><\/div><\/div><\/div><\/article><\/div><\/div><\/div><\/article><\/div><\/div><\/div><\/article><\/div><\/div><\/div><\/article><\/div><\/div><\/div><\/article><\/div><\/div><\/div><\/article><\/div><\/div><\/div><\/article><\/div><\/div><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/article><article class=\"carousel-card\"><\/article><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n<div class=\"elementor-element elementor-element-b221a4f e-con e-atomic-element e-flexbox-base e-default-div e-b221a4f-00f897e \" data-id=\"b221a4f\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"b221a4f\" data-e-type=\"e-flexbox\" data-id=\"b221a4f\">\n    <div class=\"elementor-element elementor-element-c214303 e-con e-atomic-element e-flexbox-base e-default-div e-c214303-e7b0604 \" data-id=\"c214303\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"c214303\" data-e-type=\"e-flexbox\" data-id=\"c214303\">\n    <div class=\"elementor-element elementor-element-9a2cc91 e-con e-atomic-element e-flexbox-base e-default-div e-9a2cc91-a19dea8 \" data-id=\"9a2cc91\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"9a2cc91\" data-e-type=\"e-flexbox\" data-id=\"9a2cc91\">\n    \t\t\t<h3 data-interaction-id=\"9ec358a\" class=\"e-9ec358a-f802d1d e-heading-base e-default-h3\" data-e-type=\"widget\" data-id=\"9ec358a\" >When OS takes years to mature, what should count as enough evidence?<br><\/h3>\n\t\t\t\t\t<p class=\"e-09b0c08-b3694d2 e-paragraph-base e-default-p\" data-interaction-id=\"09b0c08\" data-e-type=\"widget\" data-id=\"09b0c08\"><\/p>\n\t\t\n<\/div>\n<div class=\"elementor-element elementor-element-29e960d e-flex e-con-boxed e-con e-child\" data-id=\"29e960d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cc93758 elementor-align-center elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"cc93758\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/09\/Final-Insight-Report_Overall-Survival-in-Oncology_-When-Should-Surrogate-Endpoints-Count.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Download Full Report<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce22716 elementor-align-left elementor-widget__width-initial elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"ce22716\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/mdforlives.com\/us\/signup\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Join the Panel<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n\n<\/div>\n<div class=\"elementor-element elementor-element-40cdf53 e-flex e-con-boxed e-con e-parent\" data-id=\"40cdf53\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5f690c8 e-con e-atomic-element e-flexbox-base e-default-div e-5f690c8-cdd6487 \" data-id=\"5f690c8\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"5f690c8\" data-e-type=\"e-flexbox\" data-id=\"5f690c8\">\n    <div class=\"elementor-element elementor-element-043bf43 e-con e-atomic-element e-flexbox-base e-default-div e-043bf43-bdb90e9 \" data-id=\"043bf43\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"043bf43\" data-e-type=\"e-flexbox\" data-id=\"043bf43\">\n    <div class=\"elementor-element elementor-element-b11393c e-con-full e-flex e-con e-parent\" data-id=\"b11393c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-efc1db0 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"efc1db0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"section-tag\">The backstory<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90cde85 elementor-widget elementor-widget-heading\" data-id=\"90cde85\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The endpoint debate is now about context, not OS versus everything else\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-77f532d elementor-widget elementor-widget-text-editor\" data-id=\"77f532d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"lead\">Overall survival remains one of the clearest measures of benefit in oncology, but modern treatment sequences, crossover, long post-progression survival, molecular response, and patient-reported outcomes make the endpoint hierarchy less uniform across disease settings.<\/p><p>\u00a0<\/p><p>The MDForLives survey asks oncology and hematology clinicians where they still need mature OS, where surrogates such as PFS or EFS are credible, when molecular response can support earlier decisions, and how much quality of life, toxicity, reimbursement, and confirmatory evidence shape what happens after a positive trial. External regulatory context is moving the same way: FDA Project Endpoint examines the complementary roles of early and late endpoints, and recent FDA guidance covers core patient-reported outcomes (2024), ctDNA in early-stage solid tumors (2024), assessing OS when it is not the primary endpoint (2025 draft), and MRD and complete response as accelerated-approval endpoints in multiple myeloma (January 2026 draft).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-40b7393 e-con-full e-flex e-con e-child\" data-id=\"40b7393\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4214abf elementor-widget elementor-widget-text-editor\" data-id=\"4214abf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section class=\"finding\"><div class=\"insight-box\"><strong>MDForLives interpretation:<\/strong>\u00a0The emerging question is not whether OS still matters. It is how oncologists decide when an earlier endpoint is mature enough, clinically meaningful enough, and supported enough to act on before OS can answer every uncertainty.<\/div><\/section><section class=\"finding\"><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-df81795 e-flex e-con-boxed e-con e-parent\" data-id=\"df81795\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8391a05 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8391a05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"content-section-tag\">Finding 1<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b181037 elementor-widget elementor-widget-heading\" data-id=\"b181037\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Most clinicians keep OS, but not as a universal endpoint\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d39be5d elementor-widget elementor-widget-text-editor\" data-id=\"d39be5d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"lead\">40.4% say OS remains necessary in late-stage or relapsed settings, while surrogate endpoints should replace it in early, adjuvant, or selected settings.<\/p><div class=\"chart\">\u00a0<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eeb4f8c elementor-widget elementor-widget-html\" data-id=\"eeb4f8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<iframe src=\"https:\/\/visualize.graphy.app\/view\/da148342-1d5a-4987-858b-71546b7a1b67\" loading=\"lazy\" allowfullscreen=\"true\" style=\"width: 100%; height: 400px; border: none; border-radius: 14px;\"><\/iframe>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-669c7c1 elementor-widget elementor-widget-text-editor\" data-id=\"669c7c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section class=\"content-section\"><p>The distribution is balanced around one idea: OS still matters, but its role should depend on the disease setting. Fifteen clinicians (28.8%) would keep OS mandatory for all definitive Phase 3 approvals, another 15 (28.8%) would demote it to secondary when PFS\/EFS and QoL gains are convincing, and only one (1.9%) considers OS broadly obsolete, leaving the largest group using a setting-specific hierarchy rather than a single rule. Read against Finding 5, where 55.8% accept a robust PFS\/EFS gain without proven OS, the pattern is consistent: clinicians will act on surrogates but want the endpoint matched to the setting, turning interpretation into a case-by-case judgment about when waiting for mature survival is worth it.<\/p><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-726b07a e-con-full e-flex e-con e-child\" data-id=\"726b07a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-272cbff elementor-widget elementor-widget-text-editor\" data-id=\"272cbff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section class=\"finding\"><div class=\"insight-box\"><section class=\"finding\"><div class=\"insight-box\"><strong>What this could mean for oncologists:<\/strong>\u00a0Trial interpretation may increasingly start with the disease trajectory and treatment setting. In a long-survival or curative-intent setting, waiting for mature OS can take years; in aggressive relapsed disease, OS may remain the most consequential anchor.<\/div><\/section><section class=\"finding\"><\/section><\/div><\/section><section class=\"finding\"><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-71980ab e-flex e-con-boxed e-con e-parent\" data-id=\"71980ab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-055499e elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"055499e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"content-section-tag\"><div class=\"content-section-tag\">Finding 2<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32f74f2 elementor-widget elementor-widget-heading\" data-id=\"32f74f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">A significant OS gain is not automatically a prescribing signal\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1deda99 elementor-widget elementor-widget-text-editor\" data-id=\"1deda99\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"lead\">59.6% would offer a higher-toxicity regimen with a modest OS benefit primarily to younger, fit patients who prioritize maximum survival.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b0da05 elementor-widget elementor-widget-html\" data-id=\"9b0da05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<iframe src=\"https:\/\/visualize.graphy.app\/view\/065e22b6-706c-4b8d-a619-f7ea5bc71987\" loading=\"lazy\" allowfullscreen=\"true\" style=\"width: 100%; height: 400px; border: none; border-radius: 14px;\"><\/iframe>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d9f735 elementor-widget elementor-widget-text-editor\" data-id=\"6d9f735\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section class=\"content-section\"><section class=\"content-section\"><section class=\"content-section\"><section class=\"finding\"><p>For most respondents, a modest survival extension depends on who receives it and what toxicity they can carry: 31 of 52 clinicians make patient fitness and preference the main filter, 28.8% would routinely recommend any significant OS extension if toxicity stays manageable, and 9.6% favor the milder standard of care unless the patient asks for the aggressive option. The deeper signal is that a significant OS result is necessary but not sufficient, with fitness and tolerability as a second gate, so uptake of a modest-benefit, higher-toxicity regimen is likely to concentrate in younger, fitter patients rather than spread across all who are eligible.<\/p><\/section><section class=\"finding\"><\/section><\/section><\/section><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-409b016 e-flex e-con-boxed e-con e-parent\" data-id=\"409b016\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b2317e5 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"b2317e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"content-section-tag\"><div class=\"content-section-tag\"><div class=\"content-section-tag\">Finding 3<\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5af27b2 elementor-widget elementor-widget-heading\" data-id=\"5af27b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Molecular response is most approval-ready in blood cancers\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c50f18a elementor-widget elementor-widget-text-editor\" data-id=\"c50f18a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"lead\">46.2% identify hematologic malignancies as the disease setting most ready for negative MRD\/ctDNA status to serve as a standalone approval endpoint.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d675b0f elementor-widget elementor-widget-html\" data-id=\"d675b0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<iframe src=\"https:\/\/visualize.graphy.app\/view\/c935ea25-569e-4751-a71f-469f65342278\" loading=\"lazy\" allowfullscreen=\"true\" style=\"width: 100%; height: 400px; border: none; border-radius: 14px;\"><\/iframe>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0eb962 elementor-widget elementor-widget-text-editor\" data-id=\"e0eb962\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section class=\"content-section\"><section class=\"content-section\"><p>Nearly half choose hematologic diseases such as multiple myeloma, leukemia, and lymphoma, while 25.0% (13) choose early-stage curative solid tumors, 15.4% (8) late-stage or metastatic solid tumors, and 13.5% (7) say the evidence is not mature in any setting. The pattern mirrors the uneven maturity of molecular-response endpoints rather than blanket enthusiasm for ctDNA: grouped together, the three solid-tumor answers outweigh the hematologic vote, so this reads less as a green light for ctDNA than a judgment that only hematologic malignancies are close today, and solid-tumor programs should plan for a higher validation bar before molecular response can stand alone.<\/p><\/section><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b2e0444 e-con-full e-flex e-con e-child\" data-id=\"b2e0444\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-deeb25e elementor-widget elementor-widget-text-editor\" data-id=\"deeb25e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section class=\"finding\"><div class=\"insight-box\"><section class=\"finding\"><div class=\"insight-box\"><section class=\"finding\"><div class=\"insight-box\"><strong>Why the disease setting matters:<\/strong>\u00a0FDA has long addressed MRD as a biomarker in hematologic malignancies, and its January 2026 draft guidance specifically discusses MRD and complete response as primary endpoints for accelerated approval in multiple myeloma. In solid tumors, ctDNA is moving forward too, but assay harmonization, prognostic versus predictive meaning, and validation against clinical outcomes remain central.<\/div><\/section><section class=\"finding\"><\/section><\/div><\/section><section class=\"finding\"><\/section><\/div><\/section><section class=\"finding\"><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3c20583 e-flex e-con-boxed e-con e-parent\" data-id=\"3c20583\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9433ab5 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9433ab5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"content-section-tag\"><div class=\"content-section-tag\"><div class=\"content-section-tag\"><div class=\"content-section-tag\">Finding 4<\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7ae16b9 elementor-widget elementor-widget-heading\" data-id=\"7ae16b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">QoL matters, but differently in regulation and at the bedside\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e1bf26 elementor-widget elementor-widget-text-editor\" data-id=\"4e1bf26\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"lead\">50.0% would give validated PRO\/QoL improvements secondary regulatory weight only when they are accompanied by statistically significant PFS\/EFS gains.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0640d66 elementor-widget elementor-widget-text-editor\" data-id=\"0640d66\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section class=\"content-section\"><div class=\"bar-chart mix-chart\"><div class=\"stack-legend\"><div class=\"legend-item\"><section class=\"content-section\"><div class=\"bar-chart mix-chart\"><div class=\"stack-legend\"><div class=\"legend-item\"><section class=\"content-section\"><section class=\"finding\"><p>The regulatory view is cautious: 26 of 52 clinicians place PRO\/QoL behind a conventional efficacy signal such as PFS\/EFS, 30.8% would give a meaningful, durable QoL improvement weight equal to OS, 13.5% see it mainly as supportive labeling and counseling evidence, and only 5.8% assign it minimal weight. The bedside points the other way, symptom palliation, preserved performance, and daily QoL are the largest single driver of late-line shared decisions at 40.4%, ahead of expected OS at 32.7% and PFS\/EFS at 25.0%.<\/p><\/section><section class=\"finding\"><\/section><\/section><\/div><\/div><\/div><\/section><\/div><\/div><\/div><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5824f18 e-flex e-con-boxed e-con e-parent\" data-id=\"5824f18\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4711505 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"4711505\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"content-section-tag\"><div class=\"content-section-tag\"><div class=\"content-section-tag\"><div class=\"content-section-tag\"><div class=\"content-section-tag\">Finding 5<\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb7cd7c elementor-widget elementor-widget-heading\" data-id=\"bb7cd7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PFS\/EFS without OS is usually acceptable, but the evidence problem persists\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6381f16 elementor-widget elementor-widget-text-editor\" data-id=\"6381f16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"lead\">55.8% view a robust PFS\/EFS extension without an OS benefit as moderately acceptable and would prescribe while explaining that total lifespan has not been shown to improve.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff227e6 elementor-widget elementor-widget-html\" data-id=\"ff227e6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<iframe src=\"https:\/\/visualize.graphy.app\/view\/4548c663-757b-407d-8a3f-746c83801d47\" loading=\"lazy\" allowfullscreen=\"true\" style=\"width: 100%; height: 400px; border: none; border-radius: 14px;\"><\/iframe>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e846ade elementor-widget elementor-widget-text-editor\" data-id=\"e846ade\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section class=\"content-section\"><section class=\"content-section\"><section class=\"finding\"><p>Twenty-nine clinicians take the middle position, using the drug but separating more time without progression from longer total survival, while 30.8% (16) consider the PFS\/EFS gain fully meaningful on its own and only seven combined call it questionable or unacceptable. Access can still interrupt that acceptance: for surrogate-approved therapies, 42.3% see reimbursement or prior-authorization hurdles occasionally and 26.9% frequently, and 43.1%, the largest group, want mandatory real-world evidence tracking alongside confirmatory trials. Combined, 86.6% place PFS\/EFS in acceptable territory, so surrogate-based decisions are mainstream, but the majority at moderately acceptable plus the 43.1% demand for RWE tracking shows acceptance is conditional, shifting the evidence burden downstream to confirmation and monitoring rather than ending at approval.<\/p><\/section><section class=\"closing\"><\/section><\/section><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-07ce675 e-flex e-con-boxed e-con e-parent\" data-id=\"07ce675\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e0aadd7 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"e0aadd7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">\n<div class=\"content-section-tag\">Closing Perspective<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ab7a16c elementor-widget elementor-widget-heading\" data-id=\"ab7a16c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The debate is not OS versus surrogates, but matching evidence to the question\n<\/h2>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f312d8 e-con e-atomic-element e-flexbox-base e-default-div e-0f312d8-7b50540 \" data-id=\"0f312d8\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"0f312d8\" data-e-type=\"e-flexbox\" data-id=\"0f312d8\">\n    \t\t<div class=\"elementor-element elementor-element-2ec34b8 elementor-widget elementor-widget-text-editor\" data-id=\"2ec34b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Across the survey, clinicians are not ready to abandon overall survival; they are building a more conditional evidence hierarchy. OS remains especially important where the decision is about irreversible mortality and mature survival can be measured meaningfully, while surrogate endpoints gain credibility when waiting for OS is slow, confounded, or poorly matched to the disease setting.<\/p><p>\u00a0<\/p><p>That hierarchy shifts once the result reaches the clinic. A modest OS gain may be offered selectively as toxicity and fitness change its value, persistent MRD negativity may support de-escalation before full cessation, a PFS\/EFS benefit can justify prescribing while still requiring an explicit conversation that lifespan has not been proven, and in late-line care symptom relief, function, and daily quality of life can matter more to the patient than the endpoint that carried the trial.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<p class=\"e-9634562-d823411 e-paragraph-base e-default-p\" data-interaction-id=\"9634562\" data-e-type=\"widget\" data-id=\"9634562\"><\/p>\n\t\t\n<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n<div class=\"elementor-element elementor-element-a70cb22 e-con e-atomic-element e-flexbox-base e-default-div e-a70cb22-31755c5 \" data-id=\"a70cb22\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"a70cb22\" data-e-type=\"e-flexbox\" data-id=\"a70cb22\">\n    <div class=\"elementor-element elementor-element-4250b3a e-flex e-con-boxed e-con e-parent\" data-id=\"4250b3a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;],&quot;sticky_offset&quot;:0,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-86c8620 e-con-full e-flex e-con e-child\" data-id=\"86c8620\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1020a6e elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"1020a6e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"side-card-title\">\/\/ at a glance<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-84ddef9 e-con-full e-flex e-con e-child\" data-id=\"84ddef9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ed7942e elementor-widget elementor-widget-heading\" data-id=\"ed7942e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Total Survey Records<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-368b776 elementor-widget elementor-widget-heading\" data-id=\"368b776\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">72\n<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5b7cfe7 e-con-full e-flex e-con e-child\" data-id=\"5b7cfe7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c38a4a0 elementor-widget elementor-widget-heading\" data-id=\"c38a4a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Countries Covered\n<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b32c885 elementor-widget elementor-widget-heading\" data-id=\"b32c885\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">6<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-618b50a e-con-full e-flex e-con e-child\" data-id=\"618b50a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f630011 elementor-widget elementor-widget-heading\" data-id=\"f630011\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Specialty<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eae837a elementor-widget elementor-widget-heading\" data-id=\"eae837a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Oncologists<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a3557f3 e-con-full e-flex e-con e-child\" data-id=\"a3557f3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-28be993 elementor-widget elementor-widget-heading\" data-id=\"28be993\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Published Date\n<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2884486 elementor-widget elementor-widget-heading\" data-id=\"2884486\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">16 August 2026<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a280907 e-con-full e-flex e-con e-child\" data-id=\"a280907\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4038d33 elementor-widget elementor-widget-heading\" data-id=\"4038d33\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Completion Rate\n<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e2e27ed elementor-widget elementor-widget-heading\" data-id=\"e2e27ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">70.8%\n<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-45db9e9 e-con-full e-flex e-con e-child\" data-id=\"45db9e9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f26adbb elementor-widget elementor-widget-heading\" data-id=\"f26adbb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Survey ID\n<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fc1d487 elementor-widget elementor-widget-heading\" data-id=\"fc1d487\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">8945208\n<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8d23c78 e-con-full e-flex e-con e-child\" data-id=\"8d23c78\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d6f8026 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"d6f8026\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"side-card-title\">\/\/ browse categories<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e5a0fd3 elementor-widget elementor-widget-shortcode\" data-id=\"e5a0fd3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><div class=\"category-icons-wrapper\"><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=57\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Endocrinology-Diabetes-Metabolism_2.webp\"><h4>Endocrinology, Diabetes &amp; Metabolism<\/h4><span>7<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=63\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Oncology-Hematology.webp\"><h4>Oncology &amp; Hematology<\/h4><span>7<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=70\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Hospital-Administration.webp\"><h4>Hospital Administration<\/h4><span>6<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=56\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Dermatology.webp\"><h4>Dermatology<\/h4><span>6<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=58\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Ophthalmology-2.webp\"><h4>Ophthalmology<\/h4><span>6<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=61\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Gastroenterology-Hepatology.webp\"><h4>Gastroenterology &amp; Hepatology<\/h4><span>6<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=65\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Pharmacy.webp\"><h4>Pharmacy<\/h4><span>6<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=66\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Primary-Care-Family-Medicine.webp\"><h4>Primary Care &amp; Family Medicine<\/h4><span>6<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=68\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Surgery-Procedural-Care.webp\"><h4>Surgery &amp; Procedural Care<\/h4><span>5<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=76\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Diabetes-Weight-Metabolic-Health.webp\"><h4>Diabetes, Weight &amp; Metabolic Health<\/h4><span>5<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=59\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Neurology.webp\"><h4>Neurology<\/h4><span>5<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=60\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Dentistry-Oral-Health.webp\"><h4>Dentistry &amp; Oral Health<\/h4><span>5<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=62\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Nurses-NPs-Physician-Assistants.webp\"><h4>Nurses, NPs &amp; Physician Assistants<\/h4><span>5<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=64\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Pediatrics.webp\"><h4>Pediatrics<\/h4><span>5<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=21\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Heart_3x.webp\"><h4>Cardiology<\/h4><span>4<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=71\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Laboratory-Diagnostics-2.webp\"><h4>Laboratory &amp; Diagnostics<\/h4><span>4<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=67\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Radiology-Imaging.webp\"><h4>Radiology &amp; Imaging<\/h4><span>3<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=72\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Optometry-Optical-Care.webp\"><h4>Optometry &amp; Optical Care<\/h4><span>3<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=78\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Skin-Aesthetic-Care-copy.webp\"><h4>Skin &amp; Aesthetic Care<\/h4><span>2<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=75\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Cancer-Care.webp\"><h4>Cancer Care<\/h4><span>1<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=106\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icon__Social-Work-Patient-Support-.webp\"><h4>Social Work &amp; Patient Support<\/h4><span>1<\/span><\/a><a class=\"category-item\" href=\"https:\/\/mdforlives.com\/insights\/trends\/?cat=74\"><img decoding=\"async\" class=\"category-icon\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/08\/Icons__Brain-Nerves-Mental-Health.webp\"><h4>Brain, Nerves &amp; Mental Health<\/h4><span>1<\/span><\/a><\/div>\n\n\n<style>\n.category-icons-wrapper{\n    display: flex;\n    flex-direction: column;\n    gap: 8px;\n}\n\n\/* MAIN ITEM *\/\n.category-item{\n    display: flex;\n    align-items: center;\n    justify-content: space-between;\n    padding: 8px 12px !important;\n    border-radius: 14px;\n    background: #ffffff;\n    border: 1px solid #eeeeee;\n    text-decoration: none;\n    transition: all 0.25s ease;\n}\n\n\/* HOVER EFFECT *\/\n.category-item:hover{\n    background: #f5f8ff;\n    border-color: #dbe6ff;\n    transform: translateY(-2px);\n    box-shadow: 0 6px 14px rgba(0,0,0,0.08);\n}\n\n\/* ICON *\/\n.category-icon{\n    width: 28px !important;\n    height: 28px !important;\n    object-fit: cover;\n    border-radius: 8px;\n    flex-shrink: 0;\n}\n\n\/* NAME *\/\n.category-item h4{\n    flex: 1;\n    margin-left: 12px;\n    color: #6B7280;\n    font-size: 12px;\n    font-weight: 500;\n    margin-bottom: 0;\n}\n\n\/* COUNT *\/\n.category-item span{\n    background: #eef2ff;\n    color: #3b5bdb;\n    padding: 4px 10px;\n    border-radius: 999px;\n    font-size: 12px;\n    font-weight: 600;\n    min-width: 30px;\n    text-align: center;\n}\n<\/style><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5e0547 elementor-widget elementor-widget-image\" data-id=\"d5e0547\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"483\" height=\"583\" src=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/06\/TrendsFlyerImage.png\" class=\"attachment-large size-large wp-image-246\" alt=\"\" srcset=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/06\/TrendsFlyerImage.png 483w, https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/06\/TrendsFlyerImage-249x300.png 249w\" sizes=\"(max-width: 483px) 100vw, 483px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n\n<\/div>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-592bc40 e-con e-atomic-element e-flexbox-base e-default-div e-592bc40-e7a124a e-592bc40-e7a124a \" data-id=\"592bc40\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"592bc40\" data-e-type=\"e-flexbox\" data-id=\"592bc40\">\n    <div class=\"elementor-element elementor-element-b72c944 e-con e-atomic-element e-flexbox-base e-default-div e-b72c944-fd42483 \" data-id=\"b72c944\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"b72c944\" data-e-type=\"e-flexbox\" data-id=\"b72c944\">\n    <div class=\"elementor-element elementor-element-c122226 e-con e-atomic-element e-flexbox-base e-default-div e-c122226-bc788b3 \" data-id=\"c122226\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"c122226\" data-e-type=\"e-flexbox\" data-id=\"c122226\">\n    \t\t<div class=\"elementor-element elementor-element-836fba0 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"836fba0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>You have read the summary<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5d3255 elementor-widget elementor-widget-heading\" data-id=\"d5d3255\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">The findings go deeper.<br>So can your participation.<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2c1a57 elementor-widget elementor-widget-text-editor\" data-id=\"d2c1a57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"bottom-cta-strip-sub\"><div class=\"bottom-cta-strip-sub\"><div class=\"bottom-cta-strip-sub\"><div class=\"bottom-cta-strip-sub\"><span style=\"font-weight: 400;\">Discover the complete research behind these insights, or become part of future studies with MDForLives.<\/span><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n<div class=\"elementor-element elementor-element-41f82c2 e-flex e-con-boxed e-con e-child\" data-id=\"41f82c2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-882bb73 elementor-align-center elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"882bb73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/09\/Final-Insight-Report_Overall-Survival-in-Oncology_-When-Should-Surrogate-Endpoints-Count.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Download Full Report<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56014ba elementor-align-left elementor-widget__width-initial elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"56014ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/mdforlives.com\/us\/signup\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Join the Panel<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n\n<\/div>\n<div class=\"elementor-element elementor-element-1a8cd3c e-con e-atomic-element e-flexbox-base e-default-div e-626ff9f \" data-id=\"1a8cd3c\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"1a8cd3c\" data-e-type=\"e-flexbox\" data-id=\"1a8cd3c\">\n    <div class=\"elementor-element elementor-element-9cbf101 e-flex e-con-boxed e-con e-parent\" data-id=\"9cbf101\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-44b94c0 e-con-full e-flex e-con e-child\" data-id=\"44b94c0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a42613c elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"a42613c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"content-section-tag\"><div class=\"content-section-tag\">People also ask<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5884799 elementor-widget elementor-widget-heading\" data-id=\"5884799\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Frequently asked questions <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b2e89f elementor-widget elementor-widget-text-editor\" data-id=\"6b2e89f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"content-lead\">Direct answers to common questions around this topic.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-95c7dd1 elementor-widget elementor-widget-n-accordion\" data-id=\"95c7dd1\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;default_state&quot;:&quot;expanded&quot;,&quot;max_items_expended&quot;:&quot;one&quot;,&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:400,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1570\" class=\"e-n-accordion-item\" open>\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"true\" aria-controls=\"e-n-accordion-item-1570\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Is overall survival still the gold-standard endpoint in oncology trials? <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M177 159.7l136 136c9.4 9.4 9.4 24.6 0 33.9l-22.6 22.6c-9.4 9.4-24.6 9.4-33.9 0L160 255.9l-96.4 96.4c-9.4 9.4-24.6 9.4-33.9 0L7 329.7c-9.4-9.4-9.4-24.6 0-33.9l136-136c9.4-9.5 24.6-9.5 34-.1z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-down\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M143 352.3L7 216.3c-9.4-9.4-9.4-24.6 0-33.9l22.6-22.6c9.4-9.4 24.6-9.4 33.9 0l96.4 96.4 96.4-96.4c9.4-9.4 24.6-9.4 33.9 0l22.6 22.6c9.4 9.4 9.4 24.6 0 33.9l-136 136c-9.2 9.4-24.4 9.4-33.8 0z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1570\" class=\"elementor-element elementor-element-a672836 e-con-full e-flex e-con e-child\" data-id=\"a672836\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-99cd185 elementor-widget elementor-widget-text-editor\" data-id=\"99cd185\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"faq-item\"><div class=\"faq-a\"><div class=\"paa-item\"><div class=\"paa-a\"><div class=\"bar-chart\"><div class=\"bar-chart\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><p>Overall survival remains one of the most direct and important measures of clinical benefit because it measures how long patients live. However, oncology trials may also use validated earlier endpoints such as progression-free survival, event-free survival, response, disease-free survival, MRD, or other measures when the disease setting and evidence support them. FDA guidance increasingly addresses how OS should be assessed even when it is not the primary endpoint.<\/p><\/div><div class=\"faq-item\">\u00a0<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1571\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"2\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1571\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> What is a surrogate endpoint in an oncology clinical trial? <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M177 159.7l136 136c9.4 9.4 9.4 24.6 0 33.9l-22.6 22.6c-9.4 9.4-24.6 9.4-33.9 0L160 255.9l-96.4 96.4c-9.4 9.4-24.6 9.4-33.9 0L7 329.7c-9.4-9.4-9.4-24.6 0-33.9l136-136c9.4-9.5 24.6-9.5 34-.1z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-down\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M143 352.3L7 216.3c-9.4-9.4-9.4-24.6 0-33.9l22.6-22.6c9.4-9.4 24.6-9.4 33.9 0l96.4 96.4 96.4-96.4c9.4-9.4 24.6-9.4 33.9 0l22.6 22.6c9.4 9.4 9.4 24.6 0 33.9l-136 136c-9.2 9.4-24.4 9.4-33.8 0z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1571\" class=\"elementor-element elementor-element-43b9cc6 e-con-full e-flex e-con e-child\" data-id=\"43b9cc6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f80d23a elementor-widget elementor-widget-text-editor\" data-id=\"f80d23a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"paa-item\"><div class=\"paa-a\"><div class=\"bar-chart\"><div class=\"bar-chart\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><p>A surrogate endpoint is a laboratory, imaging, response, or other measure expected to predict clinical benefit but that is not itself a direct measure of how a patient feels, functions, or survives. In oncology, examples can include response rate, PFS, DFS, EFS, or molecular-response measures, depending on the disease and regulatory context.<\/p><\/div><div class=\"faq-item\">\u00a0<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1572\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"3\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1572\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> When can PFS or EFS be used instead of overall survival? <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M177 159.7l136 136c9.4 9.4 9.4 24.6 0 33.9l-22.6 22.6c-9.4 9.4-24.6 9.4-33.9 0L160 255.9l-96.4 96.4c-9.4 9.4-24.6 9.4-33.9 0L7 329.7c-9.4-9.4-9.4-24.6 0-33.9l136-136c9.4-9.5 24.6-9.5 34-.1z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-down\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M143 352.3L7 216.3c-9.4-9.4-9.4-24.6 0-33.9l22.6-22.6c9.4-9.4 24.6-9.4 33.9 0l96.4 96.4 96.4-96.4c9.4-9.4 24.6-9.4 33.9 0l22.6 22.6c9.4 9.4 9.4 24.6 0 33.9l-136 136c-9.2 9.4-24.4 9.4-33.8 0z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1572\" class=\"elementor-element elementor-element-704e9ed e-con-full e-flex e-con e-child\" data-id=\"704e9ed\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c90d568 elementor-widget elementor-widget-text-editor\" data-id=\"c90d568\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"paa-item\"><div class=\"paa-a\"><div class=\"bar-chart\"><div class=\"bar-chart\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><p>PFS or EFS may be appropriate when they are clinically meaningful, reliably measured, and suitable for the disease setting, especially when waiting for mature OS would take many years or be confounded by subsequent treatment. Whether they can support approval depends on the endpoint, effect size, trial design, disease context, and the totality of evidence.<\/p><\/div><div class=\"faq-item\">\u00a0<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1573\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"4\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1573\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Can MRD or ctDNA be used as an endpoint for cancer drug approval? <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M177 159.7l136 136c9.4 9.4 9.4 24.6 0 33.9l-22.6 22.6c-9.4 9.4-24.6 9.4-33.9 0L160 255.9l-96.4 96.4c-9.4 9.4-24.6 9.4-33.9 0L7 329.7c-9.4-9.4-9.4-24.6 0-33.9l136-136c9.4-9.5 24.6-9.5 34-.1z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-down\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M143 352.3L7 216.3c-9.4-9.4-9.4-24.6 0-33.9l22.6-22.6c9.4-9.4 24.6-9.4 33.9 0l96.4 96.4 96.4-96.4c9.4-9.4 24.6-9.4 33.9 0l22.6 22.6c9.4 9.4 9.4 24.6 0 33.9l-136 136c-9.2 9.4-24.4 9.4-33.8 0z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1573\" class=\"elementor-element elementor-element-7ce4d23 e-con-full e-flex e-con e-child\" data-id=\"7ce4d23\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-77858bb elementor-widget elementor-widget-text-editor\" data-id=\"77858bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div id=\"faq\" class=\"content-section\"><div class=\"faq-box\"><div class=\"faq-item\"><div class=\"faq-a\"><section class=\"content-section\"><div class=\"paa-list\"><div class=\"paa-item\"><div class=\"paa-a\"><div class=\"bar-chart\"><div class=\"bar-chart\"><div class=\"paa-section\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><p>Potentially, but not universally. FDA has guidance on MRD in hematologic malignancies and ctDNA in early-stage solid-tumor drug development. A January 2026 draft guidance specifically addresses MRD and complete response as primary endpoints to support accelerated approval in multiple myeloma. Assay performance, disease setting, and validation remain critical.<\/p><\/div><div class=\"faq-item\">\u00a0<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1574\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"5\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1574\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> How are patient-reported outcomes and quality of life used in oncology trials? <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M177 159.7l136 136c9.4 9.4 9.4 24.6 0 33.9l-22.6 22.6c-9.4 9.4-24.6 9.4-33.9 0L160 255.9l-96.4 96.4c-9.4 9.4-24.6 9.4-33.9 0L7 329.7c-9.4-9.4-9.4-24.6 0-33.9l136-136c9.4-9.5 24.6-9.5 34-.1z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-down\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M143 352.3L7 216.3c-9.4-9.4-9.4-24.6 0-33.9l22.6-22.6c9.4-9.4 24.6-9.4 33.9 0l96.4 96.4 96.4-96.4c9.4-9.4 24.6-9.4 33.9 0l22.6 22.6c9.4 9.4 9.4 24.6 0 33.9l-136 136c-9.2 9.4-24.4 9.4-33.8 0z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1574\" class=\"elementor-element elementor-element-cf36d3d e-con-full e-flex e-con e-child\" data-id=\"cf36d3d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-409fc77 elementor-widget elementor-widget-text-editor\" data-id=\"409fc77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div id=\"faq\" class=\"content-section\"><div class=\"faq-box\"><div class=\"faq-item\"><div class=\"faq-a\"><section class=\"content-section\"><div class=\"paa-list\"><div class=\"paa-item\"><div class=\"paa-a\"><div class=\"bar-chart\"><div class=\"content-section\"><div class=\"bar-chart\"><div class=\"content-section\"><div class=\"bar-chart\"><div class=\"paa-section\"><div class=\"faq-item\"><div class=\"faq-a\"><article class=\"article-content\"><div class=\"content-section\"><article class=\"article-content\"><div class=\"content-section\"><article class=\"article-content\"><div class=\"content-section\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><p>Patient-reported outcomes can capture symptoms, physical function, treatment burden, and health-related quality of life directly from patients. FDA issued final guidance in 2024 on a core set of PROs for cancer trials. Their regulatory weight depends on how they are measured, the trial design, and how they fit with efficacy and safety evidence.<\/p><\/div><div class=\"faq-item\">\u00a0<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/article><\/div><\/article><\/div><\/article><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1575\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"6\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1575\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> What does accelerated approval mean for an oncology drug? <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-up\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M177 159.7l136 136c9.4 9.4 9.4 24.6 0 33.9l-22.6 22.6c-9.4 9.4-24.6 9.4-33.9 0L160 255.9l-96.4 96.4c-9.4 9.4-24.6 9.4-33.9 0L7 329.7c-9.4-9.4-9.4-24.6 0-33.9l136-136c9.4-9.5 24.6-9.5 34-.1z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-down\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M143 352.3L7 216.3c-9.4-9.4-9.4-24.6 0-33.9l22.6-22.6c9.4-9.4 24.6-9.4 33.9 0l96.4 96.4 96.4-96.4c9.4-9.4 24.6-9.4 33.9 0l22.6 22.6c9.4 9.4 9.4 24.6 0 33.9l-136 136c-9.2 9.4-24.4 9.4-33.8 0z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1575\" class=\"elementor-element elementor-element-d403874 e-con-full e-flex e-con e-child\" data-id=\"d403874\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a22c1e elementor-widget elementor-widget-text-editor\" data-id=\"5a22c1e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div id=\"faq\" class=\"content-section\"><div class=\"faq-box\"><div class=\"faq-item\"><div class=\"faq-a\"><section class=\"content-section\"><div class=\"paa-list\"><div class=\"paa-item\"><div class=\"paa-a\"><div class=\"bar-chart\"><div class=\"content-section\"><div class=\"bar-chart\"><div class=\"content-section\"><div class=\"bar-chart\"><div class=\"paa-section\"><div class=\"faq-item\"><div class=\"faq-a\"><article class=\"article-content\"><div class=\"content-section\"><article class=\"article-content\"><div class=\"content-section\"><article class=\"article-content\"><div class=\"content-section\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-a\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><div class=\"faq-item\"><section class=\"faq-section\"><div class=\"container\"><div class=\"faq-item\"><p>FDA accelerated approval can allow earlier access to a treatment for a serious condition based on a surrogate endpoint that is reasonably likely to predict clinical benefit. Confirmatory studies are required to verify that benefit, and an indication can be withdrawn if the expected benefit is not confirmed.<\/p><\/div><\/div><\/section><section class=\"related\"><div class=\"container\"><div class=\"related-head\"><div>\u00a0<\/div><\/div><\/div><\/section><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/article><\/div><\/article><\/div><\/article><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<p class=\"e-96362bd-025437d e-paragraph-base e-default-p\" data-interaction-id=\"96362bd\" data-e-type=\"widget\" data-id=\"96362bd\">Direct answers to the questions healthcare professionals are most likely to ask about these findings.<br><\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b75f50 e-flex e-con-boxed e-con e-parent\" data-id=\"2b75f50\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5d1a15e e-grid e-con-full e-con e-child\" data-id=\"5d1a15e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dcfd188 elementor-widget elementor-widget-heading\" data-id=\"dcfd188\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Related Reports<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f05e4fa elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-heading\" data-id=\"f05e4fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><a href=\"#\">View all reports \u2192<\/a><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c97024f elementor-grid-3 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-posts--thumbnail-top elementor-widget elementor-widget-posts\" data-id=\"c97024f\" data-element_type=\"widget\" data-e-type=\"widget\" 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https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/09\/MDFL-Blogs_Insight-3-Migraine-at-Work-What-Makes-Staying-Productive-So-Difficult-1024x567.webp 1024w, https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/09\/MDFL-Blogs_Insight-3-Migraine-at-Work-What-Makes-Staying-Productive-So-Difficult-768x425.webp 768w, https:\/\/mdforlives.com\/insights\/wp-content\/uploads\/2026\/09\/MDFL-Blogs_Insight-3-Migraine-at-Work-What-Makes-Staying-Productive-So-Difficult.webp 1209w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div>\n\t\t<\/a>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/mdforlives.com\/insights\/patients-and-caregivers\/brain-nerves-and-mental-health\/migraine-at-work-what-makes-staying-productive-so-difficult\/\" >\n\t\t\t\tMigraine at Work: What Makes Staying Productive So Difficult\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tSeptember 29, 2026\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/mdforlives.com\/insights\/patients-and-caregivers\/brain-nerves-and-mental-health\/migraine-at-work-what-makes-staying-productive-so-difficult\/\" aria-label=\"Read more about Migraine at Work: What Makes Staying Productive So Difficult\" tabindex=\"-1\" >\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Oncology &amp; Hematology Insight Report Overall Survival in Oncology: When Should Surrogate Endpoints Count? A peer-level look at how oncology and hematology clinicians weigh overall survival against PFS\/EFS, MRD and ctDNA, quality of life, toxicity, reimbursement, and the evidence needed to trust accelerated approvals. Audience: Oncology &amp; Hematology Clinicians Countries: 6 Completion Rate: 70.8% SGID: 8945208 Download Full Report Join the Panel -Hero findings 0 % view a regulator-approved drug with a robust PFS\/EFS gain but no OS benefit as moderately acceptable, prescribing it while explaining that longer total lifespan has not been confirmed. say OS is necessary in late-stage<\/p>\n","protected":false},"author":1,"featured_media":23682,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[63],"tags":[],"class_list":["post-22816","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oncology-and-hematology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Obesity Treatment Costs: GLP-1 Coverage and Access<\/title>\n<meta name=\"description\" content=\"Explore how GLP-1 coverage affects obesity treatment costs, insurance access, affordability, and patient care.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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