Because most chemotherapy drugs are quite toxic, doctors and patients need to carefully balance the risks and benefits of each treatment. To avoid dangerous toxicity, many of these drugs must be given in limited doses or a limited number of times, which can also limit their effectiveness. Targeted cancer therapy includes several strategies that try to get around these limitations.
What is targeted cancer therapy?
“Targeted” implies a treatment designed to maximally impact cancer cells, like an arrow aimed at a target, while causing much less harm to other tissues.
Side effects of therapy for cancer depend on the agent but can include gastrointestinal distress and diarrhea, a weakened immune system, nerve damage and pain, easy bruising and bleeding, rashes, and other effects. Many of these side effects occur because traditional chemotherapy attacks all rapidly dividing cells, including cancerous and normal cells.


Hyperthermic chemotherapy can also be used intratumorally. For example, injection of cisplatin heated between 40 and 45°C into tumors has been investigated as a palliative treatment for peripheral non-small cell lung cancer.6 In a small study, patients treated with intratumoral cisplatin along with systemic chemotherapy had increased survival when compared with the group given systemic chemotherapy alone.6 Intratumoral injection has also been investigated to relieve malignant airway obstruction in NSCLC.7

- https://www.hcplive.com/view/a_brief_review_1009
- https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet
- https://www.medicalnewstoday.com/articles/323485#rare-side-effects
- https://www.discovermagazine.com/health/honeymoon-phase-chemical-partners-deliver-a-toxic-drug-to-tumors
- https://jamanetwork.com/journals/jamasurgery/article-abstract/2735967
- https://ejb.springeropen.com/articles/10.1186/s43168-020-00018-x
- https://pmj.bmj.com/content/98/1156/104
- https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00781
- https://clinicaltrials.gov/ct2/show/NCT04106492
- https://onlinelibrary.wiley.com/doi/epdf/10.1002/adtp.202000243

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